2. Signaling Pathways
  3. Immunology/Inflammation
    Vitamin D Related/Nuclear Receptor
  4. Glucocorticoid Receptor

Glucocorticoid Receptor

Glucocorticoid Receptor

Related Products

PDF 2.23 MB

Glucocorticoid Receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind. The GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response. When the glucocorticoid receptor binds to glucocorticoids, its primary mechanism of action is the regulation of gene transcription. The unbound receptor resides in the cytosol of the cell. After the receptor is bound to glucocorticoid, the receptor-glucorticoid complex can take either of two paths. The activated GR complex up-regulates the expression of anti-inflammatory proteins in the nucleus or represses the expression of pro-inflammatory proteins in the cytosol by preventing the translocation of other transcription factors from the cytosol into the nucleus. Dexamethasone is an agonist, and RU486 and cyproterone acetate are antagonists of the GR. Also, progesterone and DHEA have antagonist effects on the GR.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-13570CR
    Betamethasone disodium phosphate (Standard)
    		Agonist
    Betamethasone disodium phosphate (Standard) is the analytical standard of Betamethasone disodium phosphate. This product is intended for research and analytical applications. Betamethasone disodium phosphate (Betamethasone 21-phosphate disodium salt) is a kind of corticosteroid, which is commonly used in the intralesional research of keloids.
    Betamethasone disodium phosphate (Standard)
  • HY-17461S4
    Cortisone-d9
    		Agonist
    Cortisone-d9 (17-Hydroxy-11-dehydrocorticosterone-d9) is the deuterium labeled Cortisone (HY-17461). Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations.
    Cortisone-d<sub>9</sub>
  • HY-B1832R
    Prednisone acetate (Standard)
    		Agonist
    Prednisone acetate (Standard) is the analytical standard of Prednisone acetate. This product is intended for research and analytical applications. Prednisone acetate (Prednisone 21-acetate), a glucocorticoid, is an orally active Notch inhibitor. Prednisone acetate has anti-inflammatory activity and can enhance the immune response.
    Prednisone acetate (Standard)
  • HY-109026
    Benzodrocortisone
    		Agonist
    Benzodrocortisone is a glucocorticoid receptor agonist. Benzodrocortisone can be used in research on eye diseases.
    Benzodrocortisone
  • HY-151963
    PPARγ/GR modulator 1
    		Agonist
    PPARγ/GR modulator 1 is an orally active dual agonist of PPARγ and glucocorticoid receptor (GR), with Kis of 3.3 and 33.6 μM, respectively. PPARγ/GR modulator 1 can be used for the research of metabolic diseases, such as diabetes.
    PPARγ/GR modulator 1
  • HY-A0150
    Alclometasone
    		Agonist
    Alclometasone (7a-Chloro-16a-methyl prednisolone) is a glucocorticoid and inhibits the release of pro-inflammatory mediators from leukocytes. Alclometasone can be used to relieve corticosteroid-responsive dermatoses, including atopic dermatitis, eczema, psoriasis and allergic dermatitis.
    Alclometasone
  • HY-B1834S1
    Megestrol-d5
    		Agonist
    Megestrol-d5 is the deuterium labeled Megestrol. Megestrol is an orally active glucocorticoid and progesterone receptor agonist. Megestrol can alleviate anorexia, cachexia or unexplained significant weight loss associated with acquired immunodeficiency syndrome (AIDS). Megestrol may cause glucocorticoid-like effects and an increased risk of mental disorders.
    Megestrol-d<sub>5</sub>
  • HY-B0727R
    Betamethasone valerate (Standard)
    		Agonist
    Betamethasone valerate (Standard) is the analytical standard of Betamethasone valerate. This product is intended for research and analytical applications. Betamethasone valerate (Betamethasone 17-valerate), the 17-valerate ester of Betamethasone, is a topical corticosteroid with anti-inflammatory activity. Betamethasone valerate is used in the treatment of recurrent aphthous stomatitis. Betamethasone valerate inhibits the binding of the radiolabeled glucocorticoid dexamethasone (3H dexamethasone) to human epidermis and mouse skin with IC50s of 5 and 6 nM, respectively.
    Betamethasone valerate (Standard)
  • HY-100087
    Budesonide impurity C
    		Agonist 98.58%
    Budesonide impurity C is an impurity of Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist.
    Budesonide impurity C
  • HY-B0636S2
    Triamcinolone acetonide-d7-1
    		Agonist
    Triamcinolone acetonide-d7-1 is deuterium labeled Triamcinolone acetonide.
    Triamcinolone acetonide-d<sub>7</sub>-1
  • HY-121859
    RU28362
    		Agonist
    RU28362 is a potent and selective glucocorticoid agonist. RU28362 increases the Bnip3 mRNA levels in neurons. RU28362 inhibits adrenocorticotrophic hormone (ACTH) and corticosterone secretion. RU28362 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    RU28362
  • HY-14648S1
    Dexamethasone-d5-1
    		Agonist
    Dexamethasone-d5-1 is deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.
    Dexamethasone-d<sub>5</sub>-1
  • HY-B1183R
    Hydrocortisone acetate (Standard)
    		Agonist
    Hydrocortisone acetate (Standard) is the analytical standard of Hydrocortisone acetate. This product is intended for research and analytical applications.
    Hydrocortisone acetate (Standard)
  • HY-13609S
    Deflazacort-d5
    		Agonist
    Deflazacort-d5 is the deuterium labeled Deflazacort. Deflazacort, a glucocorticoid, is an inactive proagent and is converted rapidly to the active metabolite 21-desacetyldeflazacort. Deflazacort is used as an anti-inflammatory and immunosuppressant.
    Deflazacort-d<sub>5</sub>
  • HY-13609R
    Deflazacort (Standard)
    		Agonist
    Deflazacort (Standard) is the analytical standard of Deflazacort. This product is intended for research and analytical applications. Deflazacort, a glucocorticoid, is an inactive proagent and is converted rapidly to the active metabolite 21-desacetyldeflazacort. Deflazacort is used as an anti-inflammatory and immunosuppressant.
    Deflazacort (Standard)
  • HY-109017R
    Vamorolone (Standard)
    		Agonist
    Vamorolone (Standard) is the analytical standard of Vamorolone. This product is intended for research and analytical applications.
    Vamorolone (Standard)
  • HY-125922S
    (22R)-Budesonide-d6
    		Agonist
    (22R)-Budesonide-d6 (Dexbudesonide-d6) is deuterium labeled (22R)-Budesonide. (22R)-Budesonide ((22R)-BUD) is the (22R)-enantiomer of Budesonide (HY-13580). (22R)-Budesonide is a non-halogenated glucocorticoid with high local anti-inflammatory activity.
    (22R)-Budesonide-d<sub>6</sub>
  • HY-W742981
    Budesonide-d6
    		Agonist
    Budesonide-d6 is deuterium labeled Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma.
    Budesonide-d<sub>6</sub>
  • HY-103662R
    GW-870086 (Standard)
    		Agonist
    GW-870086 (Standard) is the analytical standard of GW-870086 (HY-103662). This product is intended for research and analytical applications. GW-870086 is a potent anti-inflammatory agent, acting as a glucocorticoid receptor agonist, with a pIC50 of 10.1 in A549 cells expressing NF-κB.
    GW-870086 (Standard)
  • HY-116691R
    Hydrocortisone aceponate (Standard)
    		Agonist
    Hydrocortisone aceponate (Hydrocortisone 17-propionate 21-acetate) Standard is the analytical standard of Hydrocortisone aceponate (HY-116691). This product is intended for research and analytical applications. Hydrocortisone aceponate (Hydrocortisone 17-propionate 21-acetate) is a diester-based topical glucocorticoid. Hydrocortisone aceponate alleviates symptoms such as erythema, dryness/desquamation, pruritus, epidermal exfoliation, and exudation/crusting. Hydrocortisone aceponate causes extremely few adverse reactions. Hydrocortisone aceponate is applicable to various dermatological disease studies.
    Hydrocortisone aceponate (Standard)
Cat. No. Product Name / Synonyms Application Reactivity